No the intake is relearned within 500 mi. I put 2500 into CAI, 63mm TB, 2.5" CATBack, headers and e-fan. and picked up 1-2 mpg. Honestly the best is to have the correct gearing, speedo gear, smoother tires inflated properly. Second keep it at or below 65.i just revisited mpg info from my last 1100 mi trip. ~550 to and from.
The biggest improvement I saw was the e-fan. Above 35 it doesn't need to kick on so you regain the hp from the lost by driving the mechanical fan.
Miles. Gal. Cost. Mpg(cal). Mph/ gear/rpm
255.5. 13.77. 45.03. 18.55. 65/6/2100
123. 6.388. 23.67. 19.25
113.9. 5.964. 21.46. 19.09
53.3. 3.39. 12.20. 15.42. 70/5-6/2100-2500 hills
545.7
282.2. 16.6. 61.53. 17.0. 70/6/2300hills
172.6. 9.7. 32.39. 17.79
91.4. 4.9. 16.4. 18.6
546.2
For more consistent, clean air filter, run some Injector cleaner, put in new plugs gapped correctly. You could use single platinum plugs but I'd go with double Champion 7034. Also be sure your battery is good, cleaned along with all connections including the other ends of the grounds. Oh and clean your TB and IAC.
http://www.jeepforum.com/forum/f9/cleaning-iac-throttle-body-write-up-dummies-1114849/